Massive primary B–cell mediastinal lymphoma with vascular and pulmonary hilum involvement requiring multidisciplinary approach: a case report
DOI:
https://doi.org/10.5281/zenodo.18754058Keywords:
primary mediastinal large B-cell lymphoma, superior vena cava syndrome, mediastinal massAbstract
Primary mediastinal large B-cell lymphoma (PMBL) is a distinct clinicopathologic entity that typically presents as an anterior mediastinal mass in young adults. Although systemic immunochemotherapy is the cornerstone of treatment, massive tumors may occasionally cause life threatening cardiopulmonary compromise and diagnostic uncertainty. We report the case of a 30-year-old man who presented with superior vena cava syndrome due to a giant mediastinal mass. Because of imminent cardiopulmonary risk and the inability to obtain a definitive diagnosis using minimally invasive techniques, surgical debulking was performed. Histopathological and immunohistochemical evaluation established the diagnosis of PMBL.
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Copyright (c) 2026 Rumen Iliev, Galina Kurteva, Philip Abedinov, Boyan Baev, Violeta Groudeva, Stanislav Georgiev, Lyuboslava Pampulova, Manol Sokolov, Dimitar Petkov (Author)
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