Optimizing the results of surgical treatment in geriatric patients with colorectal carcinoma
DOI:
https://doi.org/10.5281/zenodo.17954576Keywords:
geriatric surgery, colorectal surgeryAbstract
INTRODUCTION: In recent decades, there has been a growing trend toward increased life expectancy. At the same time, the number of patients with colorectal carcinoma is increasing, which leads to a greater number of patients who need surgical treatment. Age is a significant risk factor for the development of CRC, but advanced age itself is an important risk factor for postoperative morbidity and mortality.
OBJECTIVE: To analyze patients aged 75 years and older who underwent surgery for colorectal carcinoma at the Surgery Clinic of the hospital "Saint Anna" Sofia, comparing outcomes between patients who underwent elective surgery and those who underwent emergency surgery.
MATERIALS AND METHODS: We conducted a retrospective, non-randomized study of geriatric patients who underwent surgery for a 3-year period (2022-2024). We analyzed the demographic data, nosological units, comorbidities, polypharmacy, surgical techniques, length of hospital stay, postoperative complications, and mortality.
RESULTS: A total of 132 patients were operated on for colorectal carcinoma during the period: 68 men and 64 women. Elective surgery was performed in 98 patients, and 34 underwent emergency surgery. Nearly 50% were in their ninth decade of life. The relative share of comorbidity was high, above 90%. Hospital stay ranged from 1 to 31 days and was significantly longer for emergency surgeries. Mortality for elective surgery was 10.2%, while in emergency cases it reached 50%.
DISCUSSION AND CONCLUSION: The findings of our research underline the importance of optimizing the surgical treatment for geriatric patients with colorectal carcinoma. Key factors in this optimization process include accurate and timely detection of treatable pathology, a comprehensive geriatric assessment, and necessary preoperative preparation to improve physiological status, comorbidities, and specific geriatric syndromes. The appropriate choice of anesthesiological and surgical techniques, combined with adequate postoperative care and rehabilitation, further contributes to the success of the treatment. Elective surgery significantly reduces the risks of complications, morbidity, and mortality that are characteristic of emergency interventions.
References
1. Eamer G, Taheri A, Chen SS, et al. Comprehensive geriatric assessment for older people admitted to a surgical service. Cochrane Database Syst Rev. 2018;2018(1):CD012485. doi:10.1002/14651858.CD012485.pub2
2. Partridge JSL, Harari D, Martin FC, Dhesi JK. The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia. 2014;69(s1):8-16. doi:10.1111/anae.12494
3. ÇINAR F, PARLAK G, ETİ ASLAN F. The effect of comorbidity on mortality in elderly patients undergoing emergency abdominal surgery: a systematic review and metaanalysis. Turk J Med Sci. 2021;51(1):61-67. doi:10.3906/sag-2001-27
4. Skorus U, Rapacz K, Kenig J. The significance of comorbidity burden among older patients undergoing abdominal emergency or elective surgery. Acta Chir Belg. 2021;121(6):405-412. doi:10.1080/00015458.2020.1816671
5. Hewitt J, McCormack C, Tay HS, et al. Prevalence of multimorbidity and its association with outcomes in older emergency general surgical patients: an observational study. BMJ Open. 2016;6(3):e010126. doi:10.1136/bmjopen-2015-010126
6. Rosen CB, Wirtalla C, Keele LJ, et al. Multimorbidity Confers Greater Risk for Older Patients in Emergency General Surgery Than the Presence of Multiple Comorbidities: A Retrospective Observational Study. Med Care. 2022;60(8):616-622. doi:10.1097/MLR.0000000000001733
7. Pazan F, Wehling M. Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences. Eur Geriatr Med. 2021;12(3):443-452. doi:10.1007/s41999-021-00479-3
8. Alhumaidi RM, Bamagous GA, Alsanosi SM, et al. Risk of Polypharmacy and Its Outcome in Terms of Drug Interaction in an Elderly Population: A Retrospective Cross-Sectional Study. J Clin Med. 2023;12(12):3960. doi:10.3390/jcm12123960
9. Dascalu AM. REVIEW POLYPHARMACY IN GERIATRIC PATIENTS UNDERGOING SURGERY – STRATEGIES TO REDUCE THE RISK OF IATROGENIC EVENTS. FARMACIA. 2023;71(3):463-470. doi:10.31925/farmacia.2023.3.3
10. Barnett SR. Polypharmacy and perioperative medications in the elderly. Anesthesiol Clin. 2009;27(3):377-389, table of contents. doi:10.1016/j.anclin.2009.07.004
11. Niikawa H, Okamura T, Ito K, et al. Association between polypharmacy and cognitive impairment in an elderly Japanese population residing in an urban community. Geriatr Gerontol Int. 2017;17(9):1286-1293. doi:10.1111/ggi.12862
12. Wastesson JW, Morin L, Tan ECK, Johnell K. An update on the clinical consequences of polypharmacy in older adults: a narrative review. Expert Opin Drug Saf. 2018;17(12):1185-1196. doi:10.1080/14740338.2018.1546841
13. Fried TR, O’Leary J, Towle V, Goldstein MK, Trentalange M, Martin DK. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014;62(12):2261-2272. doi:10.1111/jgs.13153
14. Taniguchi T, Inagaki R, Michikawa T, et al. Polypharmacy of Older Surgical Patients With Extremity Fractures. Geriatr Orthop Surg Rehabil. 2024;15:21514593241234431. doi:10.1177/21514593241234431
15. George C, Verghese J. Polypharmacy and Gait Performance in Community Dwelling Older Adults. J Am Geriatr Soc. 2017;65(9):2082-2087. doi:10.1111/jgs.14957
16. Rawle MJ, Cooper R, Kuh D, Richards M. Associations Between Polypharmacy and Cognitive and Physical Capability: A British Birth Cohort Study. J Am Geriatr Soc. 2018;66(5):916-923. doi:10.1111/jgs.15317
17. Sganga F, Vetrano DL, Volpato S, et al. Physical performance measures and polypharmacy among hospitalized older adults: results from the CRIME study. J Nutr Health Aging. 2014;18(6):616-621. doi:10.1007/s12603-014-0029-z
18. Leelakanok N, Holcombe AL, Lund BC, Gu X, Schweizer ML. Association between polypharmacy and death: A systematic review and meta-analysis. J Am Pharm Assoc (2003). 2017;57(6):729-738.e10. doi:10.1016/j.japh.2017.06.002
19. Lertkovit S, Siriussawakul A, Suraarunsumrit P, et al. Polypharmacy in Older Adults Undergoing Major Surgery: Prevalence, Association With Postoperative Cognitive Dysfunction and Potential Associated Anesthetic Agents. Front Med (Lausanne). 2022;9:811954. doi:10.3389/fmed.2022.811954
20. Alshanberi AM. Recent Updates on Risk and Management Plans Associated with Polypharmacy in Older Population. Geriatrics (Basel). 2022;7(5):97. doi:10.3390/geriatrics7050097
21. Fugang W, Zhaopeng Y, Meng Z, Maomin S. Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta-analysis. Mol Clin Oncol. 2017;7(5):771-776. doi:10.3892/mco.2017.1419
22. Ngu JCY, Kuo LJ, Teo NZ. Minimally invasive surgery in the geriatric patient with colon cancer. J Gastrointest Oncol. 2020;11(3):540-544. doi:10.21037/jgo.2020.02.02
23. Alamri AM, Gharzan SASA, Alosaimi AGM, et al. The Impact of Minimally Invasive Surgical Techniques on Long-term Outcomes in Elderly Patients with Colorectal Cancer: A Systematic Review. Saudi Medical Horizons Journal. 2025;5(2):130-137. doi:10.54293/smhj.v5i2.146
24. Robinson CN, Balentine CJ, Marshall CL, et al. Minimally invasive surgery improves short-term outcomes in elderly colorectal cancer patients. J Surg Res. 2011;166(2):182-188. doi:10.1016/j.jss.2010.05.053
25. Calu V, Piriianu C, Miron A, Grigorean VT. Surgical Site Infections in Colorectal Cancer Surgeries: A Systematic Review and Meta-Analysis of the Impact of Surgical Approach and Associated Risk Factors. Life (Basel). 2024;14(7):850. doi:10.3390/life14070850
26. Seishima R, Miyata H, Okabayashi K, et al. Safety and feasibility of laparoscopic surgery for elderly rectal cancer patients in Japan: a nationwide study. BJS Open. 2021;5(2):zrab007. doi:10.1093/bjsopen/zrab007
27. Błeszyńska E, Wierucki Ł, Zdrojewski T, Renke M. Pharmacological Interactions in the Elderly. Medicina (Kaunas). 2020;56(7):320. doi:10.3390/medicina56070320
28. Mangoni AA, Jackson SHD. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57(1):6-14. doi:10.1046/j.1365-2125.2003.02007.x
29. Staheli B, Rondeau B. Anesthetic Considerations in the Geriatric Population. In: StatPearls. StatPearls Publishing; 2025. Accessed April 30, 2025. http://www.ncbi.nlm.nih.gov/books/NBK572137/
30. Smetana GW, Lawrence VA, Cornell JE, American College of Physicians. Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians. Ann Intern Med. 2006;144(8):581-595. doi:10.7326/0003-4819-144-8-200604180-00009
31. Irwin MG, Ip KY, Hui YM. Anaesthetic considerations in nonagenarians and centenarians. Curr Opin Anaesthesiol. 2019;32(6):776-782. doi:10.1097/ACO.0000000000000793
32. Ramly E, Kaafarani HMA, Velmahos GC. The effect of aging on pulmonary function: implications for monitoring and support of the surgical and trauma patient. Surg Clin North Am. 2015;95(1):53-69. doi:10.1016/j.suc.2014.09.009
33. Tran D, Rajwani K, Berlin DA. Pulmonary effects of aging. Curr Opin Anaesthesiol. 2018;31(1):19-23. doi:10.1097/ACO.0000000000000546
34. Rooke GA. Cardiovascular aging and anesthetic implications. J Cardiothorac Vasc Anesth. 2003;17(4):512-523. doi:10.1016/s1053-0770(03)00161-7
35. Lakatta EG. Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons. Heart Fail Rev. 2002;7(1):29-49. doi:10.1023/A:1013797722156
36. Frasson M, Braga M, Vignali A, Zuliani W, Di Carlo V. Benefits of laparoscopic colorectal resection are more pronounced in elderly patients. Dis Colon Rectum. 2008;51(3):296-300. doi:10.1007/s10350-007-9124-0
37. Devoto L, Celentano V, Cohen R, Khan J, Chand M. Colorectal cancer surgery in the very elderly patient: a systematic review of laparoscopic versus open colorectal resection. Int J Colorectal Dis. 2017;32(9):1237-1242. doi:10.1007/s00384-017-2848-y
38. Hamel MB, Henderson WG, Khuri SF, Daley J. Surgical outcomes for patients aged 80 and older: morbidity and mortality from major noncardiac surgery. J Am Geriatr Soc. 2005;53(3):424-429. doi:10.1111/j.1532-5415.2005.53159.x
39. Shin R, Lee SM, Sohn B, et al. Predictors of Morbidity and Mortality After Surgery for Intestinal Perforation. Ann Coloproctol. 2016;32(6):221-227. doi:10.3393/ac.2016.32.6.221
40. Racz J, Dubois L, Katchky A, Wall W. Elective and emergency abdominal surgery in patients 90 years of age or older. Can J Surg. 2012;55(5):322-328. doi:10.1503/cjs.007611
41. Type of Surgery and Its Risk Level Has Significant Impact on Complications and Death in Elderly Patients. ACS. Accessed August 23, 2025. https://www.facs.org/media-center/press-releases/2024/type-of-surgery-and-its-risk-level-has-significant-impact-on-complications-and-death-in-elderly-patients/
42. Khan-Kheil A, Khan H. Surgical mortality in patients more than 80 years of age. Ann R Coll Surg Engl. 2016;98(3):177-180. doi:10.1308/rcsann.2015.0043
43. Turrentine FE, Wang H, Simpson VB, Jones RS. Surgical risk factors, morbidity, and mortality in elderly patients. J Am Coll Surg. 2006;203(6):865-877. doi:10.1016/j.jamcollsurg.2006.08.026
44. Barbosa T de A, Souza AMF de, Leme FCO, et al. [Perioperative complications and mortality in elderly patients following surgery for femoral fracture: prospective observational study]. Braz J Anesthesiol. 2019;69(6):569-579. doi:10.1016/j.bjan.2019.09.004
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