A mucinous neoplasm of the appendix

Short literature review and case report

Authors

  • Georgi Gendov MHAT Burgasmed - Burgas Author
  • Petko Dimov MHAT Burgasmed - Burgas Author
  • Kristiana Panayotova MHAT Burgasmed - Burgas Author

DOI:

https://doi.org/10.5281/zenodo.17949716

Keywords:

Mucinous neoplasms of the appendix, appendectomy, LAMN

Abstract

Mucinous neoplasms of the appendix are a rare pathology with nonspecific or missing clinical appearance and typical CT findings. Occasional finding of such a process during laparotomy/laparoscopy is even rarer nowadays. The vast majority of surgeons know little about the various cases and the appropriate management for each. 
We present the case of H.H, a 64-year-old female, admitted to the General Surgery Ward of MPHAT – Burgasmed after a query appendicular neoplasm, which was confirmed by the Imaging Department Team and surgically treated in our clinic. Appendectomy and atypical ablastic resection of the coecum were performed. After an uneventful postoperative period, the patient was discharged home with a recommendation for follow-up at the Complex Oncology Centre – Burgas. 

References

1. Smeenk, R. M., van Velthuysen, M. L., Verwaal, V. J., et al. Appendiceal Neoplasms and Pseudomyxoma Peritonei: A Population-Based Study. European Journal of Surgical Oncology 34 (2008): 196–201.

2. Tirumani, H. S., Fraser-Hill, M., Auer, R., Shabana, W., Walsh, C., Lee, F., and Ryan, J. G. Mucinous Neoplasms of the Appendix: A Current Comprehensive Clinicopathologic and Imaging Review. Cancer Imaging 13 (2013): 14-25.

3. Gonzalez, H. H., Herard, K., and Mijares, M. C. A Rare Case of Low-Grade Appendiceal Mucinous Neoplasm: A Case Report. Cureus 11 (2019): e3980. https://doi.org/10.7759/cureus.3980.

4. Pape, U. F., Niederle, B., Costa, F., et al. Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas). Neuroendocrinology 103, no. 2 (2016): 144-52. PMID: 26730583.

5. Copur, M., Cushman-Vokoun, A., Padussis, J., et al. Mucinous Adenocarcinoma of the Appendix with Histologic Response to Neoadjuvant Chemotherapy: Review of Histologic and Clinical Spectrum of Epithelial Neoplastic Mucinous Lesions of the Appendix. Oncology (Williston Park) 35 (2021): 335-340.

6. Misdraji, J. Mucinous Epithelial Neoplasms of the Appendix and Pseudomyxoma Peritonei. Modern Pathology 28 (2015): S67-S79. https://doi.org/10.1038/modpathol.2014.129.

7. Tiselius, C., Kindler, C., Shetye, J., Letocha, H., and Smedh, K. "Computed Tomography Follow-Up Assessment of Patients with Low-Grade Appendiceal Mucinous Neoplasms: Evaluation of Risk for Pseudomyxoma Peritonei. Annals of Surgical Oncology 24 (2017): 1778-1782.

8. Szych C, Staebler A, Connolly DC, Wu R, Cho KR, Ronnett BM. Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women. Am J Pathol. 1999 Jun;154(6):1849-55. doi: 10.1016/S0002-9440(10)65442-9. PMID: 10362811; PMCID: PMC1866622.

9. Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y. Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms. Br J Cancer. 2013 Mar 5;108(4):951-8. doi: 10.1038/bjc.2013.47. Epub 2013 Feb 12. PMID: 23403822; PMCID: PMC3590682.

10. Liao X, Vavinskaya V, Sun K, Hao Y, Li X, Valasek M, Xu R, Polydorides AD, Houldsworth J, Harpaz N. Mutation profile of high-grade appendiceal mucinous neoplasm. Histopathology. 2020 Feb;76(3):461-469. doi: 10.1111/his.13986. Epub 2019 Dec 23. PMID: 31491041.

Downloads

Published

16.12.2025

Issue

Section

CASE REPORT

How to Cite

Gendov, G., Dimov, P., & Panayotova, K. (2025). A mucinous neoplasm of the appendix: Short literature review and case report. Surgery, 89(4). https://doi.org/10.5281/zenodo.17949716