Impact of мalabsorptive bariatric surgery on liver function and preoperative hepatic steatosis in morbidly obese patient
DOI:
https://doi.org/10.5281/zenodo.14860333Keywords:
Morbid Obesity, Nonalcoholic Fatty Liver Disease, Hepatic steatosis, Chronic Hepatitis, Biliopancreatic Diversion with Duodenal Switch, Liver Enzymes, BMIAbstract
A retrospective and prospective study was conducted on preoperative hepatic steatosis and postoperative liver function in 141 morbidly obese patients treated with the surgical technique Biliopancreatic Derivation with Duodenal Switch (BPD DS) during the period from January 2003 to June 2013 in University Hospital Center Albacete (Centro Hospitalario Universitario de Albacete – CHUA).The meanage of the patients was41.8 years (21-60y), mean weight -139.13kg (100-193kg),height - 164.22cm (141-192cm), mean BodyMassIndex (BMI) – 51.91kg/m2 (41.62-75.06 kg/m2).A liver biopsy was performed intraoperatively in 124 patients.Nonalcoholic fatty liver disease (NAFLD) was found in 90.3% of patients with wide-ranging severity, and chronic hepatitis was found only in 1.4% of the patients. A statistically significant correlation between the severity of NAFLD and BMI was not established. Postoperatively, the elevation of liver enzymes GOT and GPT was most significant in the first 3 months but in the range of 50-100 UI. Chronologically, transaminase levels returned to normal, and in the 5th year after the operation, 4,9 % of patients had slightly elevated levels of GOT and GPT below 100 UI.
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