Significant prognostic factors for anastomotic leakage after colorectal resection
DOI:
https://doi.org/10.5281/zenodo.15275972Keywords:
colorectal anastomosis, anastomotic insufficiency, colorectal resection, risk factors, survival, postoperative period, complicationAbstract
INTRODUCTION: Anastomosic leakage after colorectal resection is a complication that requires reliable methods for prevention and early diagnosis which are also related to assessment of predictive factors for its occurrence.
OBJECTIVE: To analyze various factors that are presented in the literature as risksfor anastomotic insufficiency after colorectal resection.
METHODS: A study (combined in design - prospective and retrospective) was conducted, covering 410 patients who underwent colorectal resection with anastomosis. Multivariative statistical analysis was performed on a number of factors for their potential impact on the presence of insufficiency.
RESULTS: Statistical significance for colorectal anastomosis insufficiency was established for 8 of 21 studied factors (age (p = 0.001), use of mechanical stapler (p <0.0001), intraoperative blood loss (p = 0.001), type of anastomosis (p = 0.005), tumor localization relative to LAR (p <0.0001), postoperative value of total protein (p = 0.049) and albumin (p <0.0001), amount of secretion from extraperitoneal drainages of 1, 2 and 3 POD (p <0.0001)).
CONCLUSIONS: The identification of predictive factors for anastomotic insufficiency is the basis of prevention and timely approach in the treatment of this complication.
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